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M9471033.TXT
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1994-08-09
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Document 1033
DOCN M9471033
TI Developing and implementing guidelines to promote appropriate use of
fluconazole therapy in an AIDS clinic.
DT 9409
AU Anassi EO; Egbunike IG; Akpaffiong MJ; Ike EN; Cate TR; Texas Southern
University, College of Pharmacy and Health; Sciences, Houston.
SO Hosp Pharm. 1994 Jun;29(6):576-8, 581-2, 585-6. Unique Identifier :
AIDSLINE AHA/94266663
AB A retrospective and concurrent drug use evaluation for fluconazole in an
outpatient AIDS clinic is described. Eighty-eight patient charts were
reviewed in the evaluation during an 8-week period, and 72 patients were
studied in the concurrent evaluation for a period of 5 weeks. A set of
preestablished fluconazole usage and dosing guidelines was developed by
the clinical pharmacist and the chairman of the antimicrobial
subcommittee/chief of infectious disease and approved by the pharmacy
and therapeutics committee. Patients who did not meet these guidelines
were those being treated for oropharyngeal and esophageal candidiasis.
The use of fluconazole was not indicated in 43 of 54 (80%) patients in
retrospective evaluation and 31 of 39 (79.5%) patients before clinical
pharmacist intervention in concurrent study. If guidelines had been
followed during the retrospective evaluation, cost savings would have
been $295 per day, which adds up to $16,520 for 8 weeks. In the actual
evaluation, the cost savings with pharmacist intervention for 5 weeks
was $5,460, which can be extrapolated to annual cost savings of $65,520.
DE AIDS-Related Opportunistic Infections/*DRUG THERAPY Concurrent Review
Cost Savings/STATISTICS & NUMER DATA Drug Costs/*STATISTICS & NUMER
DATA *Drug Utilization Review/ECONOMICS
Fluconazole/*ECONOMICS/*THERAPEUTIC USE Human Outpatient Clinics,
Hospital/ECONOMICS/*STANDARDS Patient Care Team Pharmacy Service,
Hospital/ECONOMICS/*STANDARDS *Practice Guidelines Retrospective
Studies Texas JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).